Key takeaways
- The label names each step, the minimum time on it and the maximum.
- After one half-life, half remains. After five, about three percent.
- How long a medicine stays is not how long it works.
- Your own schedule is set by your prescriber.
Chart a dose
An estimate from the label's half-life, not a blood test. Reko does not suggest doses, and this is not medical advice.
What this tool does
This page sets out the dose steps for Ozempic by week, the maximum, and how a half-life gives a rough idea of how long an amount stays. Every dose and half-life here comes from the current U.S. label. Other countries can differ.
How the arithmetic works
Amount remaining after t = start × 0.5(t ÷ half-life). After 1 half-life, 50%. After 2, 25%. After 3, 12.5%. After 5, about 3%.
A worked example
The label says it stays in the circulation for about 5 weeks after the last dose.
The dose steps in the U.S. label
After 0.5 mg, each step is at least 4 weeks, so these are the earliest possible weeks. Ozempic is approved in the U.S. for type 2 diabetes.
| Weeks | Weekly dose | Note |
|---|---|---|
| 1–4 | 0.25 mg | Starting dose, not for glucose control |
| 5–8 | 0.5 mg | First treatment dose |
| 9–12 | 1 mg | If more glucose control is needed |
| 13 onward | 2 mg | Maximum |
Half-life: about 1 week (label section 12.3).
Maximum dose: 2 mg once a week.
Frequently asked questions
What is the maximum Ozempic dose?
2 mg once a week.
How long does Ozempic stay in the body?
The label says it stays in the circulation for about 5 weeks after the last dose.
Can I change step early?
That is for your prescriber.
How Reko does this in the app
Reko lets you set a titration schedule for any dose steps and shows an estimated level from your logged doses and the compound's published half-lives. It is an estimate, not a blood test.
Reko records what you and your prescriber decide. It never suggests a dose, and this page is not medical advice.
- Ozempic U.S. prescribing information (revised June 2026), DailyMed.